Genetic Predisposition and Inflammatory Bowel Disease

A genetic predisposition for colorectal cancer in inflammatory bowel disease.

Gut Microbiota in Inflammatory Bowel Disease

The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a genetic predisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of "dysbiosis", with alterations of the gut microbial...

Linking Genotype with Phenotype in Inflammatory Bowel Disease – Will We Ever Have Reagent Standard Patients?

Genetic factors predispose to a number of gastrointestinal diseases. The spectrum of genetic determination may vary from classical inherited diseases such as haemochromatosis where the genetic mutation is now fairly well defined to complex polygenic diseases, such as inflammatory bowel disease and coeliac disease. In inflammatory bowel disease, genetic predisposition confers disease susceptibil...

Application of extracellular vesicles in the treatment of inflammatory bowel disease

Introduction: Inflammatory bowel disease(IBD) is caused by genetic, environmental, microbial and immune factors. IBD has two primary forms: Ulcerative colitis and Crohn´s disease. The incidence of IBD has significantly increased over the last few decades. Given that patients have poor response to drug treatments or are resistant to drug therapies, new therapies are needed for gastrointestinal i...

Genetics of Spondyloarthropathies and Inflammatory Bowel Disease: Searching for Common Susceptibility Factors

Ileocolonoscopic evidence for subclinical gut inflammation is found in a subpopulation of spondyloarthropathy (SpA) patients. The prevalence of microscopic intestinal lesions is even higher and can be classified as either an acute or a chronic type of inflammation. The latter condition is associated with an increased risk of developing overt inflammatory bowel disease (IBD), especially Crohn’s ...